What is the first emotional reaction that usually follows a dose of heroin?

The typical first emotional reaction following a dose of heroin is a state of inactivity. Heroin is an opioid that results in a profound sense of euphoria or relaxation, but it also leads to sedation and an overall reduction in physical and mental activity. Users often experience a sense of calmness and heaviness in their limbs, which can be characterized as a state of inactivity. This response is due to the way heroin interacts with the brain's opioid receptors, which depress the central nervous system, leading to decreased energy and alertness.

In contrast, while relief, stress, or weightlessness may happen at different points during heroin use or may be experienced differently by individuals, they are not the initial emotional responses following a dose of the drug. The immediate reaction tends to favor that slowed, inactive state that can make users feel detached from their surroundings.